A cancerous tumor of the eye, retinoblastoma affects the cells of the retina. Relatively simple, the diagnosis is sometimes still too late. However, clinical signs such as a white reflection in the pupil or the presence of strabismus are well known and must involve an ophthalmological examination as soon as possible. The precocity of the diagnosis conditions the implementation of treatments preserving the vision as well as possible. The Institut Curie is the reference center in France for the management of retinoblastoma.